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Apr 22

Learning Diagnostic Reasoning for Decision Support in Toxicology

Acute poly-substance intoxication requires rapid, life-saving decisions under substantial uncertainty, as clinicians must rely on incomplete ingestion details and nonspecific symptoms. Effective diagnostic reasoning in this chaotic environment requires fusing unstructured, non-medical narratives (e.g. paramedic scene descriptions and unreliable patient self-reports or known histories), with structured medical data like vital signs. While Large Language Models (LLMs) show potential for processing such heterogeneous inputs, they struggle in this setting, often underperforming simple baselines that rely solely on patient histories. To address this, we present DeToxR (Decision-support for Toxicology with Reasoning), the first adaptation of Reinforcement Learning (RL) to emergency toxicology. We design a robust data-fusion engine for multi-label prediction across 14 substance classes based on an LLM finetuned with Group Relative Policy Optimization (GRPO). We optimize the model's reasoning directly using a clinical performance reward. By formulating a multi-label agreement metric as the reward signal, the model is explicitly penalized for missing co-ingested substances and hallucinating absent poisons. Our model significantly outperforms its unadapted base LLM counterpart and supervised baselines. Furthermore, in a clinical validation study, the model indicates a clinical advantage by outperforming an expert toxicologist in identifying the correct poisons (Micro-F1: 0.644 vs. 0.473). These results demonstrate the potential of RL-aligned LLMs to synthesize unstructured pre-clinical narratives and structured medical data for decision support in high-stakes environments.

  • 6 authors
·
Mar 30

VectorGym: A Multitask Benchmark for SVG Code Generation, Sketching, and Editing

We introduce VectorGym, a comprehensive benchmark suite for Scalable Vector Graphics (SVG) that spans generation from text and sketches, complex editing, and visual understanding. VectorGym addresses the lack of realistic, challenging benchmarks aligned with professional design workflows. Our benchmark comprises four tasks with expert human-authored annotations: the novel Sketch2SVG task (VG-Sketch); a new SVG editing dataset (VG-Edit) featuring complex, multi-step edits with higher-order primitives; Text2SVG generation (VG-Text); and SVG captioning (VG-Cap). Unlike prior benchmarks that rely on synthetic edits, VectorGym provides gold-standard human annotations that require semantic understanding and design intent. We also propose a multi-task reinforcement learning approach that jointly optimizes across all four tasks using rendering-based rewards. Our method, built on GRPO with curriculum learning, trains a Qwen3-VL 8B model that achieves state-of-the-art performance among open-source models, surpassing much larger models including Qwen3-VL 235B and matching GPT-4o. We also introduce a VLM-as-a-Judge metric for SVG generation, validated through human correlation studies. Our evaluation of frontier VLMs reveals significant performance gaps, positioning VectorGym as a rigorous framework for advancing visual code generation. VectorGym is publicly available on huggingface.co/datasets/ServiceNow/VectorGym.

  • 16 authors
·
Feb 22 1

Clinical-R1: Empowering Large Language Models for Faithful and Comprehensive Reasoning with Clinical Objective Relative Policy Optimization

Recent advances in large language models (LLMs) have shown strong reasoning capabilities through large-scale pretraining and post-training reinforcement learning, demonstrated by DeepSeek-R1. However, current post-training methods, such as Grouped Relative Policy Optimization (GRPO), mainly reward correctness, which is not aligned with the multi-dimensional objectives required in high-stakes fields such as medicine, where reasoning must also be faithful and comprehensive. We introduce Clinical-Objective Relative Policy Optimization (CRPO), a scalable, multi-objective, verifiable reinforcement learning method designed to align LLM post-training with clinical reasoning principles. CRPO integrates rule-based and verifiable reward signals that jointly optimize accuracy, faithfulness, and comprehensiveness without relying on human annotation. To demonstrate its effectiveness, we train Clinical-R1-3B, a 3B-parameter model for clinical reasoning. The experiments on three benchmarks demonstrate that our CRPO substantially improves reasoning on truthfulness and completeness over standard GRPO while maintaining comfortable accuracy enhancements. This framework provides a scalable pathway to align LLM reasoning with clinical objectives, enabling safer and more collaborative AI systems for healthcare while also highlighting the potential of multi-objective, verifiable RL methods in post-training scaling of LLMs for medical domains.

  • 9 authors
·
Nov 29, 2025

SALT: Step-level Advantage Assignment for Long-horizon Agents via Trajectory Graph

Large Language Models (LLMs) have demonstrated remarkable capabilities, enabling language agents to excel at single-turn tasks. However, their application to complex, multi-step, and long-horizon tasks remains challenging. While reinforcement learning (RL) offers a promising avenue for addressing these challenges, mainstream approaches typically rely solely on sparse, outcome-based rewards, a limitation that becomes especially problematic for group-based RL algorithms lacking critic models, such as Group Relative Policy Optimization (GRPO). In such methods, uniformly rewarding or penalizing all actions within a trajectory can lead to training instability and suboptimal policies, because beneficial and detrimental actions are often entangled across multi-step interactions. To address this challenge, we propose SALT, a novel and lightweight framework that provides a finer-grained advantage assignment, derived solely from outcome rewards. We achieve this by constructing a graph from trajectories of the same prompt, which allows us to quantify the quality of each step and assign advantages accordingly. Crucially, SALT is designed as a plug-and-play module that seamlessly integrates with existing group-based RL algorithms, requiring no modifications to the rollout procedure and introducing negligible computational overhead. Extensive experiments on the WebShop, ALFWorld, and AppWorld benchmarks with various model sizes demonstrate that SALT consistently improves performance. We also conduct a thorough analysis to validate the design choices behind SALT and offer actionable insights.

  • 8 authors
·
Oct 22, 2025

Evolution Strategies at the Hyperscale

We introduce Evolution Guided General Optimization via Low-rank Learning (EGGROLL), an evolution strategies (ES) algorithm designed to scale backprop-free optimization to large population sizes for modern large neural network architectures with billions of parameters. ES is a set of powerful blackbox optimisation methods that can handle non-differentiable or noisy objectives with excellent scaling potential through parallelisation. Na{ï}ve ES becomes prohibitively expensive at scale due to the computational and memory costs associated with generating matrix perturbations EinR^{mtimes n} and the batched matrix multiplications needed to compute per-member forward passes. EGGROLL overcomes these bottlenecks by generating random matrices Ain R^{mtimes r}, Bin R^{ntimes r} with rll min(m,n) to form a low-rank matrix perturbation A B^top that are used in place of the full-rank perturbation E. As the overall update is an average across a population of N workers, this still results in a high-rank update but with significant memory and computation savings, reducing the auxiliary storage from mn to r(m+n) per layer and the cost of a forward pass from O(mn) to O(r(m+n)) when compared to full-rank ES. A theoretical analysis reveals our low-rank update converges to the full-rank update at a fast Oleft(1{r}right) rate. Our experiments show that (1) EGGROLL does not compromise the performance of ES in tabula-rasa RL settings, despite being faster, (2) it is competitive with GRPO as a technique for improving LLM reasoning, and (3) EGGROLL enables stable pre-training of nonlinear recurrent language models that operate purely in integer datatypes.

  • 16 authors
·
Nov 20, 2025

BigCharts-R1: Enhanced Chart Reasoning with Visual Reinforcement Finetuning

Charts are essential to data analysis, transforming raw data into clear visual representations that support human decision-making. Although current vision-language models (VLMs) have made significant progress, they continue to struggle with chart comprehension due to training on datasets that lack diversity and real-world authenticity, or on automatically extracted underlying data tables of charts, which can contain numerous estimation errors. Furthermore, existing models only rely on supervised fine-tuning using these low-quality datasets, severely limiting their effectiveness. To address these issues, we first propose BigCharts, a dataset creation pipeline that generates visually diverse chart images by conditioning the rendering process on real-world charts sourced from multiple online platforms. Unlike purely synthetic datasets, BigCharts incorporates real-world data, ensuring authenticity and visual diversity, while still retaining accurate underlying data due to our proposed replotting process. Additionally, we introduce a comprehensive training framework that integrates supervised fine-tuning with Group Relative Policy Optimization (GRPO)-based reinforcement learning. By introducing novel reward signals specifically designed for chart reasoning, our approach enhances model robustness and generalization across diverse chart styles and domains, resulting in a state-of-the-art chart reasoning model, BigCharts-R1. Extensive experiments demonstrate that our models surpass existing methods on multiple chart question-answering benchmarks compared to even larger open-source and closed-source models.

  • 16 authors
·
Aug 13, 2025