pmcid int32 60k 5.98M | pmid int32 11.7M 30M | text stringlengths 793 4.78k | label class label 2
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2,944,158 | 20,831,782 | BACKGROUND
Peripheral intravenous device (IVD) complications were traditionally thought to be reduced by limiting dwell time. Current recommendations are to resite IVDs by 96 hours with the exception of children and patients with poor veins. Recent evidence suggests routine resite is unnecessary, at least if devices ... | 0no significant effect |
2,871,176 | 19,317,822 | AIM
To compare the effects of combining liraglutide (0.6, 1.2 or 1.8 mg/day) or rosiglitazone 4 mg/day (all n >or= 228) or placebo (n = 114) with glimepiride (2-4 mg/day) on glycaemic control, body weight and safety in Type 2 diabetes.
METHODS
In total, 1041 adults (mean +/- sd), age 56 +/- 10 years, weight 82 +/- ... | 1significant effect |
2,708,184 | 19,523,207 | BACKGROUND
While manually-assisted body-weight supported treadmill training (BWSTT) has revealed improved locomotor function in persons with post-stroke hemiparesis, outcomes are inconsistent and it is very labor intensive. Thus an alternate treatment approach is desirable. Objectives of this pilot study were to: 1) ... | 0no significant effect |
2,864,284 | 20,409,302 | BACKGROUND
Afghanistan's national guidelines recommend chloroquine for the treatment of Plasmodium vivax infection, the parasite responsible for the majority of its malaria burden. Chloroquine resistance in P. vivax is emerging in Asia. Therapeutic responses across Afghanistan have not been evaluated in detail.
METHO... | 1significant effect |
3,187,863 | 21,749,629 | OBJECTIVE
To investigate possible differences in operative delivery rate among low-risk women, randomised to an alongside midwifery-led unit or to standard obstetric units within the same hospital.
DESIGN
Randomised controlled trial.
SETTING
Department of Obstetrics and Gynaecology, Østfold Hospital Trust, Tromsø... | 0no significant effect |
2,688,140 | 19,239,703 | INTRODUCTION
In acute respiratory distress syndrome (ARDS), adequate positive end-expiratory pressure (PEEP) may decrease ventilator-induced lung injury by minimising overinflation and cyclic recruitment-derecruitment of the lung. We evaluated whether setting the PEEP using decremental PEEP titration after an alveola... | 0no significant effect |
2,517,154 | 18,556,683 | BACKGROUND
Endometriosis is associated with an inflammatory response. Hence infliximab, an anti-TNF-alpha monoclonal antibody, might relieve pain.
METHODS
A randomized placebo-controlled trial was designed with 21 women with severe pain and a rectovaginal nodule of at least 1 cm. After 1 month of observation, three... | 0no significant effect |
2,691,927 | 19,430,829 | BACKGROUND
Laparoscopic surgery has become popular during the last decade, mainly because it is associated with fewer postoperative complications than the conventional open approach. It remains unclear, however, if this benefit is observed after laparoscopic correction of perforated peptic ulcer (PPU). The goal of th... | 1significant effect |
1,468,428 | 16,545,140 | BACKGROUND
Enemas are used during labour in obstetric settings with the belief that they reduce puerperal and neonatal infections, shorten labour duration, and make delivery cleaner for attending personnel. However, a systematic review of the literature found insufficient evidence to support the use of enemas. The ob... | 0no significant effect |
2,690,844 | 19,259,615 | OBJECTIVES
To determine whether a transverse incision is an alternative to a midline incision in terms of incisional hernia incidence, surgical site infection, postoperative pain, hospital stay and cosmetics in cholecystectomy. Incisional hernias after midline incision are commonly underestimated but probably complic... | 1significant effect |
3,090,298 | 21,573,091 | PURPOSE
To compare differences in visual acuity, contrast sensitivity, complications, and higher-order ocular aberrations (HOAs) in eyes with stable myopia undergoing either photo-refractive keratectomy (PRK) or thin-flap laser in situ keratomileusis (LASIK) (intended flap thickness of 90 μm) using the VISX Star S4 C... | 0no significant effect |
3,387,601 | 21,745,374 | INTRODUCTION
Respiratory failure is a life threatening complication of Guillain Barré syndrome (GBS). There is no consensus on the specific treatment for this subset of children with GBS.
METHODS
This was a prospective randomized study to compare the outcome of intravenous immunoglobulin (IVIG) and plasma exchange ... | 1significant effect |
2,447,617 | 18,447,940 | BACKGROUND
Severe traumatic brain injury (TBI) has been increasing with greater incidence of injuries from traffic or sporting accidents. Although there are a number of animal models of TBI using progesterone for head injury, the effects of progesterone on neurologic outcome of acute TBI patients remain unclear. The ... | 1significant effect |
1,187,893 | 15,924,620 | BACKGROUND
Studies on exercise in knee osteoarthritis (OA) have focused on elderly subjects. Subjects in this study were middle-aged with symptomatic and definite radiographic knee osteoarthritis. The aim was to test the effects of a short-term, high-intensity exercise program on self-reported pain, function and qual... | 1significant effect |
1,831,737 | 17,388,666 | BACKGROUND
HIV-1 control in sub-Saharan Africa requires cost-effective and sustainable programmes that promote behaviour change and reduce cofactor sexually transmitted infections (STIs) at the population and individual levels.
METHODS AND FINDINGS
We measured the feasibility of community-based peer education, free... | 0no significant effect |
1,876,597 | 17,525,792 | OBJECTIVES
To compare the efficacy and safety of artemether-lumefantrine (AL) and dihydroartemisinin-piperaquine (DP) for treating uncomplicated falciparum malaria in Uganda.
DESIGN
Randomized single-blinded clinical trial.
SETTING
Apac, Uganda, an area of very high malaria transmission intensity.
PARTICIPANTS
... | 1significant effect |
3,446,002 | 23,056,681 | OBJECTIVE
This study was designed to determine the effect of clofibrate on neonatal uncomplicated jaundice treated with home phototherapy.
METHODS
This clinical trial study was performed on 60 newborns with jaundice that received home phototherapy. Inclusion criteria were body weight between 2500 to 4000 gr, breast... | 1significant effect |
1,913,177 | 17,372,669 | BACKGROUND
Reconstruction of giant midline abdominal wall hernias is difficult, and no data are available to decide which technique should be used. It was the aim of this study to compare the "components separation technique" (CST) versus prosthetic repair with e-PTFE patch (PR).
METHOD
Patients with giant midline ... | 0no significant effect |
2,720,945 | 19,624,838 | BACKGROUND
The clinical effects of mucolytics in patients with chronic obstructive pulmonary disease (COPD) are discussed controversially. Cineole is the main constituent of eucalyptus oil and mainly used in inflammatory airway diseases as a mucolytic agent. We hypothesised that its known mucolytic, bronchodilating a... | 1significant effect |
2,922,723 | 19,703,826 | BACKGROUND
High frequency chest wall oscillation (HFCWO) is standard treatment for airway clearance in the USA and has recently been introduced in the UK and Europe. There is little published research comparing HFCWO with airway clearance techniques (ACTs) frequently used in the UK and Europe. The aim of this study w... | 1significant effect |
2,575,601 | 18,759,980 | INTRODUCTION
Experimental research has demonstrated that the level of neuroprotection conferred by the various barbiturates is not equal. Until now no controlled studies have been conducted to compare their effectiveness, even though the Brain Trauma Foundation Guidelines recommend that such studies be undertaken. Th... | 1significant effect |
2,430,614 | 18,575,626 | BACKGROUND
Artesunate+amodiaquine (AS+AQ) and artemether-lumefantrine (AL) are now the most frequently recommended first line treatments for uncomplicated malaria in Africa. Artesunate+chlorproguanil-dapsone (AS+CD) was a potential alternative for treatment of uncomplicated malaria. A comparison of the efficacy and s... | 0no significant effect |
4,139,977 | 25,161,987 | BACKGROUND
Evidence has shown beneficial effects of probiotics in the treatment of irritable bowel syndrome (IBS); however, there is still a lack of data in this regard. We evaluated the efficacy of a multi-strain probiotic compound on IBS symptoms and quality-of-life (QOL).
MATERIALS AND METHODS
Adult IBS patients... | 0no significant effect |
4,819,709 | 26,805,720 | BACKGROUND
The aim of this study was to assess behavioural recovery from the patient's perspective as a prespecified secondary outcome in a multicentre parallel-group randomized clinical trial comparing ultrasound-guided foam sclerotherapy (UGFS), endovenous laser ablation (EVLA) and surgery for the treatment of prim... | 0no significant effect |
2,888,205 | 20,353,551 | INTRODUCTION
Although exercise is therapeutic for adults with fibromyalgia (FM), its symptoms often create obstacles that discourage exercise. We evaluated the effects of accumulating at least 30 minutes of self-selected lifestyle physical activity (LPA) on perceived physical function, pain, fatigue, body mass index,... | 0no significant effect |
3,198,285 | 21,900,148 | OBJECTIVE
The prevalence of gestational diabetes mellitus (GDM) is rising. There is little evidence to demonstrate the effectiveness of one dietary therapy over another. We aimed to investigate the effect of a low-glycemic index (LGI) versus a conventional high-fiber diet on pregnancy outcomes, neonatal anthropometry... | 1significant effect |
2,829,413 | 20,195,400 | BACKGROUND/AIMS
This multicenter, open-labeled, randomized trial was performed to compare the effects of rosuvastatin 10 mg and atorvastatin 10 mg on lipid and glycemic control in Korean patients with nondiabetic metabolic syndrome.
METHODS
In total, 351 patients who met the modified National Cholesterol Education ... | 1significant effect |
5,577,662 | 28,854,973 | BACKGROUND
To determine the safety and efficacy of collagenase clostridium histolyticum (CCH) injection for the treatment of palmar Dupuytren disease nodules.
METHODS
In this 8-week, double-blind trial, palpable palmar nodules on one hand of adults with Dupuytren disease were selected for treatment. Patients were r... | 1significant effect |
1,475,568 | 16,533,388 | BACKGROUND
Self-management programs for patients with heart failure can reduce hospitalizations and mortality. However, no programs have analyzed their usefulness for patients with low literacy. We compared the efficacy of a heart failure self-management program designed for patients with low literacy versus usual ca... | 1significant effect |
3,108,665 | 21,694,864 | BACKGROUND
Somatostatin has been found to be effective in the prevention of postoperative complications in pancreatic surgery. It can inhibit the pancreatic secretions that, quite often, are responsible for complications during the postoperative period.
METHODS
We randomized 67 patients in 2 groups. In the study gr... | 1significant effect |
1,261,533 | 16,179,089 | BACKGROUND
The use of antimalarial drug combinations with artemisinin derivatives is recommended to overcome drug resistance in Plasmodium falciparum. The fixed combination of oral artemether-lumefantrine, an artemisinin combination therapy (ACT) is highly effective and well tolerated. It is the only registered fixed... | 0no significant effect |
4,785,315 | 26,936,901 | OBJECTIVES
We sought evidence of effectiveness of lay support to improve maternal and child outcomes in disadvantaged families.
DESIGN
Prospective, pragmatic, individually randomised controlled trial.
SETTING
3 Maternity Trusts in West Midlands, UK.
PARTICIPANTS
Following routine midwife systematic assessment o... | 0no significant effect |
5,062,194 | 27,746,564 | BACKGROUND
Anxiety is a concern in obstetrics, especially in preeclamptic mothers. Sedation is not commonly used in parturients for fear of adverse neonatal effect. We investigated maternal and neonatal outcome of midazolam as an adjuvant to spinal anesthesia for elective cesarean delivery.
METHODS
A prospective ra... | 1significant effect |
4,794,897 | 26,983,672 | BACKGROUND
To compare the effects of resistance training versus passive physical therapy on bone turnover markers (BTM) in the metastatic bone during radiation therapy (RT) in patients with spinal bone metastases. Secondly, to evaluate an association of BTM to local response, skeletal-related events (SRE), and number... | 1significant effect |
3,349,250 | 22,568,998 | BACKGROUND
In a randomised phase III trial of treatment-naive patients with metastatic renal cell carcinoma, sunitinib showed significant improvement in progression-free survival (PFS) compared with interferon (IFN)-α. We assessed between-treatment differences in overall benefit using a quality-adjusted Time Without ... | 1significant effect |
3,221,331 | 21,371,991 | BACKGROUND
Advances in technology allowed the development of a novel smoking cessation program delivered by video messages sent to mobile phones. This social cognitive theory-based intervention (called "STUB IT") used observational learning via short video diary messages from role models going through the quitting pr... | 0no significant effect |
4,078,386 | 25,002,886 | BACKGROUND
Lipid metabolism is one of the hepatitis C virus (HCV) life cycle steps. Statins can reduce cholesterol level and finally can decrease HCV replication. Thus, we assessed the effect of Statins in combination with standard antiviral treatment on hyperlipidemic genotype I HCV infected patients.
MATERIALS AND ... | 0no significant effect |
5,729,252 | 29,237,441 | BACKGROUND
No drugs have been approved for the treatment of patients with pulmonary hypertension (PH) secondary to idiopathic pulmonary fibrosis (IPF), particularly those with idiopathic honeycomb lung. This study was conducted to investigate the long-term efficacy and safety of bosentan for PH based on changes in pr... | 1significant effect |
2,974,815 | 21,049,213 | OBJECTIVES
To evaluate the importance of providing guidelines to patients via active telephone calls for blood pressure control and for preventing the discontinuation of treatment among hypertensive patients.
INTRODUCTION
Many reasons exist for non-adherence to medical regimens, and one of the strategies employed t... | 1significant effect |
4,320,624 | 25,398,689 | BACKGROUND
Long-acting β2-adrenergic agonists (LABAs) are recommended in combination with inhaled corticosteroids (ICSs) for asthma management. Abediterol is a novel, selective, potent, once-daily LABA in development for treatment of asthma and chronic obstructive pulmonary disease. This study aimed to determine abed... | 1significant effect |
3,278,655 | 22,206,447 | BACKGROUND AND PURPOSE
The trabecular metal tibial monoblock component (TM) is a relatively new option available for total knee arthroplasty. We have previously reported a large degree of early migration of the trabecular metal component in a subset of patients. These implants all appeared to stabilize at 2 years. We... | 0no significant effect |
4,889,691 | 27,279,849 | INTRODUCTION
Whether the AutoPulse automated chest compression device is worthy of clinical use for out-of-hospital cardiac arrest (OHCA) remains controversial. A prospective controlled study was conducted to evaluate the effect of AutoPulse versus manual chest compression for cardiopulmonary resuscitation (CPR) of O... | 1significant effect |
1,198,254 | 16,080,791 | BACKGROUND
In persons without clinical symptom it is difficult to assess an impact of probiotics regarding its effect on health. We evaluated the functional efficacy of the probiotic Lactobacillus fermentum ME-3 in healthy volunteers by measuring the influence of two different formulations on intestinal lactoflora, f... | 1significant effect |
5,551,012 | 28,808,578 | BACKGROUND
Babies are increasingly being exposed to antibiotics intrapartum in the bid to reduce neonatal and maternal deaths. Intrapartum antibiotic exposure, including even those considered safe in pregnancy, have been associated with childhood obesity and compromised immunity. Data on the extent of antibiotic use,... | 0no significant effect |
2,656,477 | 19,243,603 | BACKGROUND
To examine the effects of a 6 month lifestyle intervention on quality of life, depression, self-efficacy and eating behavior changes in overweight and obese endometrial cancer survivors.
METHODS
Early stage endometrial cancer survivors were randomized to intervention (n = 23) or usual care (n = 22) group... | 1significant effect |
5,209,819 | 28,049,481 | BACKGROUND
Tanzania has seen a reduction in the fraction of fevers caused by malaria, likely due in part to scale-up of control measures. While national guidelines require parasite-based diagnosis prior to treatment, it is estimated that more than half of suspected malaria treatment-seeking in Tanzania initiates in t... | 1significant effect |
5,519,461 | 28,674,348 | Objective CYP2C19 metabolic activity influences the efficacy of Helicobacter pylori eradication therapies comprising PPIs. Rabeprazole (RPZ) and esomeprazole (EPZ) are PPIs not extensively metabolized by CYP2C19. The aim of this study was to elucidate whether or not first-line triple therapies using RPZ or EPZ are equa... | 0no significant effect |
4,221,638 | 24,267,513 | BACKGROUND
Traumatic brain injury (TBI) is commonly accompanied by intracranial bleeding which can worsen after hospital admission. Tranexamic acid (TXA) has been shown to reduce bleeding in elective surgery and there is evidence that short courses of TXA can reduce rebleeding in spontaneous intracranial haemorrhage.... | 0no significant effect |
4,138,383 | 25,127,539 | BACKGROUND
Several hospitals in Norway provide short self-referral inpatient treatment to patients with severe mental diagnosis. No studies have compared the experiences of patients who have had the opportunity to self-refer to inpatient treatment with patients who have received treatment as usual. This qualitative s... | 1significant effect |
4,748,685 | 26,861,865 | BACKGROUND
One of the most effective current approaches to preventing stroke events is the reduction of lifestyle risk factors, such as unhealthy diet, physical inactivity and smoking. In this study, we assessed the efficacy and usability of the phone-based Computer-aided Prevention System (CAPSYS) in supporting the ... | 1significant effect |
3,224,529 | 21,955,588 | BACKGROUND
Mechanical ventilation seems to occupy a major source in alteration in the quality and quantity of sleep among patients in intensive care. Quality of sleep is negatively affected with frequent patient-ventilator asynchronies and more specifically with modes of ventilation. The quality of sleep among ventil... | 1significant effect |
3,971,783 | 24,719,691 | BACKGROUND
The nocturnal enuresis is one of the most common complaints of childhood. Upper airway obstruction and nocturnal snoring affect the nocturnal enuresis in children.
OBJECTIVES
The aim of this study was to investigate the effects of breathing exercises on the nocturnal enuresis in the children with the sle... | 1significant effect |
5,122,238 | 27,904,586 | BACKGROUND
Post- and intra-operative shivering is one of the most complications of spinal anesthesia so recommend a suitable drug with at least complications for prevention and control of postoperative shivering. This current study aimed to compare the preventive effect of hydrocortisone on intra- and post-operative ... | 1significant effect |
4,667,210 | 26,634,058 | BACKGROUND/OBJECTIVES
Lactobacillus brevis G101 suppresses the absorption of monosodium glutamate (MSG) from the intestine into the blood in mice. Therefore, the attenuating effect of orally administered G101 on monosodium glutamate (MSG) symptom complex was investigated in humans.
MATERIALS/METHODS
Capsules (300 m... | 0no significant effect |
5,610,854 | 29,082,039 | PURPOSE
To compare laser peripheral iridotomy (LPI) with trabeculectomy as an initial treatment for primary angle-closure glaucoma (PACG) with peripheral anterior synechiae (PAS) ≥ 6 clock hours.
METHODS
Patients were drawn from two randomized controlled trials. 38 eyes of 38 patients (PAS ≥ 6 clock hours) were tre... | 1significant effect |
4,082,484 | 24,972,677 | BACKGROUND
Curry, one of the most popular foods in Japan, contains spices that are rich in potentially antioxidative compounds, such as curcumin and eugenol. Oxidative stress is thought to impair endothelial function associated with atherosclerosis, a leading cause of cardiovascular events. The aim of this study was ... | 1significant effect |
3,491,047 | 23,061,875 | BACKGROUND
The implementation of evidence based clinical practice guidelines on self-management interventions to patients with chronic diseases is a complex process. A multifaceted strategy may offer an effective knowledge translation (KT) intervention to promote knowledge uptake and improve adherence in an effective... | 0no significant effect |
2,920,262 | 20,682,030 | BACKGROUND
Despite optimal pharmacological therapy and pulmonary rehabilitation, patients with COPD continue to be breathless. There is a need to develop additional strategies to alleviate symptoms. Learning to sing requires control of breathing and posture and might have benefits that translate into daily life.
METH... | 1significant effect |
3,577,738 | 23,437,310 | OBJECTIVE
Internet-delivered interventions can effectively change health risk behaviors and their determinants, but adherence to intervention websites once they are accessed is very low. This study tests whether and how social presence elements can increase website use.
METHODS
A website about Hepatitis A, B, and C... | 0no significant effect |
5,003,313 | 27,625,757 | BACKGROUND
The restless legs syndrome is a sensorimotor disorder that is very common in patients on hemodialysis. Due to pharmacological treatments which have their own side effects, nowadays, studies have turned to non-pharmacological treatments.
OBJECTIVES
The present study aims to assess the effect of stretching... | 1significant effect |
3,895,597 | 24,466,452 | BACKGROUND/AIMS
Antispasmodics such as octylonium are widely used to manage irritable bowel syndrome (IBS) symptoms. However, the efficacy and safety of another antispasmodic, tiropramide, remain uncertain. We aimed to evaluate the efficacy and safety of tiropramide compared with octylonium in patients with IBS.
METH... | 0no significant effect |
5,101,425 | 27,847,701 | BACKGROUND
Coronary artery bypass grafting (CABG) is a common surgical intervention at the end-stages of coronary artery occlusion disease. Despite the effectiveness of CABG, it may have particular complications, such as bleeding during and after surgery. So far, there have been many drugs used to reduce bleeding.
OB... | 1significant effect |
3,742,017 | 23,951,557 | BACKGROUND
By school age, even low risk moderately preterm-born children show more neuro-cognitive deficits, underachievement, behavioral problems, and poor social adaptation than full-term peers.
AIM
To evaluate the outcomes at school-age for moderately preterm-born children (29-33 weeks gestational age), appropri... | 1significant effect |
5,100,099 | 27,821,162 | BACKGROUND
Neurally Adjusted Ventilatory Assist (NAVA) is a mode of assisted mechanical ventilation that delivers inspiratory pressure proportionally to the electrical activity of the diaphragm. To date, no pediatric study has focused on the effects of NAVA on hemodynamic parameters. This physiologic study with a ran... | 0no significant effect |
4,940,009 | 27,462,175 | OBJECTIVE
Despite the many complications of succinylcholine, it is still widely used as a superior muscle relaxant for rapid sequence induction. One of these complications is postoperative myalgia (POM). The aim of this study was to investigate the prophylactic effect of low-dose ketamine on the incidence and severit... | 0no significant effect |
5,489,138 | 28,680,915 | OBJECTIVE
To assess the comparative utility of disability progression measures in primary progressive MS (PPMS) using the PROMiSe trial data set.
METHODS
Data for patients randomized to placebo (n = 316) in the PROMiSe trial were included in this analysis. Disability was assessed using change in single (Expanded Di... | 1significant effect |
5,936,036 | 29,736,130 | BACKGROUND
We have developed a structured cognitive behavioral therapy manual for anxiety disorder in China, and the present study evaluated the applicability of simplified cognitive behavioral therapy based on our previous research.
AIMS
To evaluate the applicability of simplified cognitive behavioral therapy (SCB... | 0no significant effect |
3,296,686 | 22,412,837 | BACKGROUND
Insulin resistance (IR) is induced by chronic hepatitis C virus (HCV) genotypes 1 and 4 infections. It is not known whether drugs that affect IR such as Pioglitazone and Prednisone also affect serum HCV RNA titers independently of PEG-Interferon-α2/ribavirin treatment. The primary aim was to assess whether... | 1significant effect |
4,821,313 | 27,054,007 | INTRODUCTION
The rapid decline in renal function caused by radiographic contrast agents usually is transient, but it can result in chronic kidney disease. The pathophysiology of contrast-induced nephropathy (CIN) is poorly understood, but it may include acute hypoxia-induced oxidative stress and free radicals generat... | 1significant effect |
5,002,324 | 27,568,011 | BACKGROUND
The present study examined the effects of a balance-based exergaming intervention using the Kinect sensor on postural stability and balance in people with Parkinson's disease (PD).
METHODS
We conducted a subject-blinded, randomized controlled study. Twenty people with PD (Hoehn and Yahr stages I through ... | 1significant effect |
4,306,068 | 25,635,196 | BACKGROUND
Acute pain assessment in the emergency department (ED) is important in particular during the triage process. Early pain assessment and management improve outcome. The objective of this study was to determine the effects of documentation and display of patient's self-assessment of pain using numerical ratin... | 0no significant effect |
5,018,157 | 27,642,568 | BACKGROUND
Despite controversies about the safest anesthetic technique for cesarean delivery in severely preeclamptic women, there is evidence that supports the use of spinal anesthesia in this group of patients.
OBJECTIVES
This prospective randomized clinical trial was designed to determine the hemodynamic effects... | 0no significant effect |
4,895,766 | 27,313,426 | INTRODUCTION
Prevalence of diabetes and its complications have been a burden to the society from the ancient times, in the present and also will be in the future unless proper measures are taken to prevent its manifestation. There have been an increasing number of death associated-amputation cases which are mainly ca... | 1significant effect |
5,626,376 | 29,026,341 | PURPOSE
To assess the effectiveness of viscosupplementation or platelet-rich plasma (PRP), compared to standard care, for pain relief after knee arthroscopic debridement in patients with meniscal pathology and osteoarthritis (OA), under normal clinical practice conditions.
PATIENTS AND METHODS
We conducted a prospe... | 1significant effect |
4,713,214 | 26,816,685 | BACKGROUND
Resiniferatoxin (RTX) has been shown to have variable efficacy in the treatment of intractable lower urinary tract symptoms and symptoms associated with neurogenic detrusor overactivity. It has also been used successfully in treating overactive bladder (OAB). In order to evaluate the potential and efficien... | 1significant effect |
3,597,472 | 23,516,656 | INTRODUCTION
More than 80% of schistosomiasis patients in China live in the lake and marshland regions. The purpose of our study is to assess the effect of a comprehensive strategy to control transmission of Schistosoma japonicum in marshland regions.
METHODOLOGY/PRINCIPAL FINDINGS
In a cluster randomized controlle... | 1significant effect |
4,803,984 | 26,493,430 | BACKGROUND & OBJECTIVES
Prolonged labor leads to increase of cesarean deliveries, reduction of fetal heart rate, and maternal as well as infantile complications. Therefore, many women tend to use pharmacological or non-pharmacological methods for reduction of labor length. The present study aimed to compare the effec... | 1significant effect |
4,132,637 | 24,727,884 | AIMS
The optimal platelet inhibition strategy for ACS patients managed without revascularization is unknown. We aimed to evaluate efficacy and safety of ticagrelor vs. clopidogrel in the non-ST-elevation acute coronary syndrome (NSTE-ACS) subgroup of the PLATO trial, in the total cohort, and in the subgroups managed ... | 0no significant effect |
3,636,800 | 23,563,184 | BACKGROUND
Mobile phone-based assessment may represent a cost-effective and clinically effective method of monitoring psychotic symptoms in real-time. There are several software options, including the use of native smartphone applications and text messages (short message service, SMS). Little is known about the stren... | 1significant effect |
4,124,480 | 25,088,030 | BACKGROUND
The effectiveness of clinic-based pulmonary rehabilitation in advanced COPD is well established, but few data exist for less severe patients treated in alternative settings. The purpose of this study was to investigate whether a novel, community-based exercise program (CBE) was feasible and effective for p... | 0no significant effect |
5,673,730 | 29,142,561 | OBJECTIVE
To evaluate and compare feto-maternal outcomes and glycemic control in metformin versus insulin treated gestational diabetics.
METHODS
The study was conducted in 2010- 2012 as a part of M. Phil at Civil hospital, Lyari General Hospital and Mamji Hospital in Karachi. After written informed consent, 71 GDM ... | 1significant effect |
2,694,465 | 19,488,583 | OBJECTIVES
To evaluate the effects of intrathecal morphine on pulmonary function, analgesia, and morphine plasma concentrations after cardiac surgery.
INTRODUCTION
Lung dysfunction increases morbidity and mortality after cardiac surgery. Regional analgesia may improve pulmonary outcomes by reducing pain, but the oc... | 1significant effect |
5,506,592 | 28,699,550 | BACKGROUND
Dengue is a serious public health issue that affects households in endemic areas in terms of health and also economically, imposing costs for prevention and treatment of cases. The Camino Verde cluster-randomised controlled trial in Mexico and Nicaragua assessed the impact of evidence-based community engag... | 1significant effect |
3,466,198 | 23,056,520 | BACKGROUND
Acidform gel, an acid-buffering product that inactivates spermatozoa, may be an effective topical non-hormonal contraceptive. This study was designed to evaluate the safety of vaginal dosing and effects of Acidform on mucosal immune mediators, antimicrobial properties of genital secretions, and vaginal mic... | 0no significant effect |
3,056,193 | 21,431,013 | INTRODUCTION
This paper describes a fictitious study of a fictitious drug. A companion paper in this issue of the Indian J Psychiatry critically examines this paper and provides author, reader, reviewer, and researcher perspectives on problems related to the design and conduct of a clinical trial; on issues related t... | 0no significant effect |
4,488,484 | 26,132,859 | BACKGROUND
Barriers to public support for naloxone distribution include lack of knowledge, concerns about potential unintended consequences, and lack of sympathy for people at risk of overdose.
METHODS
A randomized survey experiment was conducted with a nationally-representative web-based survey research panel (GfK... | 1significant effect |
5,414,544 | 28,328,795 | OBJECTIVES
To examine hepatitis B (HBV) serological markers and plasma DNA concentrations in a large group of untreated HBV/HIV-coinfected individuals in two sub-Saharan settings.
DESIGN
Baseline analysis of a randomized controlled trial.
METHODS
DART was a large trial of treatment monitoring practices in HIV-inf... | 1significant effect |
4,880,652 | 27,146,615 | OBJECTIVES
To compare the combination of paracetamol (20 mg/kg) and propofol to fentanyl (1 µg/kg) and propofol in terms of providing adequate analgesia and a comparable recovery profile in suction termination procedures.
METHODS
This is a prospective, randomized clinical study in which we obtained informed consent... | 1significant effect |
3,585,965 | 22,950,522 | BACKGROUND AND OBJECTIVES
GLPG0259 is a small-molecule inhibitor of mitogen-activated protein kinase-activated protein kinase 5 (MAPKAPK5), a kinase enzyme that plays a role in important inflammatory pathways. The main objectives of the phase I clinical studies in early development were to characterize the pharmacoki... | 0no significant effect |
5,336,430 | 27,995,485 | INTRODUCTION
Due to the high prevalence of actinic keratosis (AK) and potential for lesions to become cancerous, clinical guidelines recommend that all are treated. The objective of this study was to evaluate the efficacy and safety of 5-fluorouracil (5-FU) 0.5%/salicylic acid 10% as field-directed treatment of AK le... | 1significant effect |
4,859,395 | 26,811,165 | BACKGROUND
We hypothesized that nebivolol, a β-blocker with nitric oxide-mediated activity, compared with atenolol, a β-blocker without such activity, would decrease oxidative stress and improve the effects of endothelial dysfunction and wall shear stress (WSS), thereby reducing atherosclerosis progression and vulner... | 1significant effect |
3,406,743 | 22,515,969 | INTRODUCTION
Latinas are more likely to be inactive than non-Hispanic white women. Although 74% of Latinas report no leisure-time activity, few interventions have been designed to promote physical activity among these women. The objective of this study was to assess the effect of the California WISEWOMAN program on l... | 1significant effect |
2,837,815 | 20,198,403 | BACKGROUND
Introduction of new bone cements into clinical practice should include radiostereometric studies.
MATERIALS AND METHODS
A prospective randomised radiostereometric study was performed, comparing SmartSet HV and Palacos R acrylic bone cements (without antibiotics) using third-generation cementing technique... | 0no significant effect |
4,222,592 | 24,279,738 | BACKGROUND
The behavioral outcome of food ingestion is a complex process that involves psychological and biological factors. Avocados are nutrient dense with properties that may favorably impact energy balance. This study sought to evaluate if incorporating approximately one half of a Hass avocado by addition or incl... | 1significant effect |
4,673,066 | 26,498,597 | INTRODUCTION
Schema-based instruction has been shown to improve diagnostic performance and reduce cognitive load. However, to date, this has only been studied in controlled research settings. More distractions in classrooms may limit generalizability to real-world settings. We evaluated whether schema-based instructi... | 0no significant effect |
4,365,564 | 25,802,575 | BACKGROUND
Previous reports of lumbar total disc replacement (TDR) have described significant complications. The US Food and Drug Administration (FDA) investigational device exemption (IDE) study of the Charité artificial disc represents the first level I data comparison of TDR to fusion.
METHODS
In the prospective... | 0no significant effect |
2,627,861 | 19,165,383 | BACKGROUND
Prenatal lead exposure is associated with deficits in fetal growth and neurodevelopment. Calcium supplementation may attenuate fetal exposure by inhibiting mobilization of maternal bone lead and/or intestinal absorption of ingested lead.
OBJECTIVE
Our goal was to evaluate the effect of 1,200 mg dietary c... | 1significant effect |
3,464,379 | 22,935,960 | AIMS/HYPOTHESIS
The aim of this study was to determine whether oral dosing with N-acetylcysteine (NAC) increases intraplatelet levels of the antioxidant, glutathione (GSH), and reduces platelet-monocyte conjugation in blood from patients with type 2 diabetes.
METHODS
In this placebo-controlled randomised crossover ... | 0no significant effect |
5,593,173 | 28,892,513 | BACKGROUND
The placebo effect is usually studied in clinical settings for decreasing negative symptoms such as pain, depression and anxiety. There is interest in exploring the placebo effect also outside the clinic, for enhancing positive aspects of performance or cognition. Several studies indicate that placebo can ... | 0no significant effect |
5,741,263 | 29,272,301 | BACKGROUND
In previous work, we found that intensive amplitude training successfully improved micrographia in Parkinson's disease (PD). Handwriting abnormalities in PD also express themselves in stroke duration and writing fluency. It is currently unknown whether training changes these dysgraphic features.
OBJECTIVE
... | 1significant effect |
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