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0e92133c9b682a28ac91ea5d2c6fcb9d | Lapatinib ( LPT ) could sensitize human epidermal growth factor receptor-2 ( HER-2 ) positive breast cancer to paclitaxel ( PTX ) and induce synergetic action with PTX in preclinical test and phase II/III trial . | [
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] | A novel combined micellar system of lapatinib and Paclitaxel with enhanced antineoplastic effect against human epidermal growth factor receptor-2 positive breast tumor in vitro. Lapatinib ( LPT ) could sensitize human epidermal growth factor receptor-2 ( HER-2 ) positive breast cancer to paclitaxel ( PTX ) and induce ... | https://pubmed.ncbi.nlm.nih.gov/25421492/ | ### Instruction:
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A novel combined micellar system of lapatinib and Paclitaxel with enhanced ant... |
32a61c25a4ad01c272675f512c603206 | Two of nine patients received 15 mg/kg bevacizumab IV , 90 mg/m(2 ) irinotecan orally for five consecutive days , 100 mg/m(2)/day temozolomide IV for 5 days , and 1.5 mg/m(2 ) vincristine IV , each administered every 21 days . | [
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] | Response to bevacizumab, irinotecan, and temozolomide in children with relapsed medulloblastoma: a multi-institutional experience. Chemotherapy for relapsed medulloblastoma has been inadequate, and most patients succumb to disease. ### methods We retrospectively reviewed nine cases of relapsed medulloblastoma treated w... | https://pubmed.ncbi.nlm.nih.gov/23296323/ | ### Instruction:
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Response to bevacizumab, irinotecan, and temozolomide in children with relapse... |
8153038603c4967e7f15cff9488531d3 | These findings may help clinicians identify patients for whom acamprosate and naltrexone may be most beneficial . | [
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] | Baseline trajectories of drinking moderate acamprosate and naltrexone effects in the COMBINE study. The COMBINE study evaluated the effects of acamprosate, naltrexone, and the Combined Behavioral Intervention (CBI). In secondary analyses, our goals were to identify trajectories of any drinking prior to randomization, t... | https://pubmed.ncbi.nlm.nih.gov/21143249/ | ### Instruction:
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26cdeb8104e8e3213f01593e3d4ec34a | From August 2002 to August 2004 , 42 patients with metastatic breast cancer were recruited for treatment with pegylated liposomal doxorubicin 40 mg/m(2 ) intravenously ( i.v . ) on day 1 and vinorelbine 30 mg/m(2 ) i.v . on days 1 and 15 every 4 weeks . | [
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] | Multicenter phase II study of pegylated liposomal doxorubicin in combination with vinorelbine as first-line treatment in elderly patients with metastatic breast cancer. This multicenter phase II trial was conducted to analyze the clinical activity and toxicity of the combination of pegylated liposomal doxorubicin and v... | https://pubmed.ncbi.nlm.nih.gov/19209014/ | ### Instruction:
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Multicenter phase II study of pegylated liposomal doxorubicin in combination w... |
3bc93c0827679996e6c214c767d3824d | The aim of the present study was to investigate the combined effects of simvastatin and exemestane on MCF-7 human breast cancer cells . | [
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] | Synergistic effects of combined treatment with simvastatin and exemestane on MCF-7 human breast cancer cells. Breast cancer is associated with high levels of incidence, morbidity and mortality; therefore, the identification of effective chemopreventive strategies is crucial. It is important for clinicians to be able to... | https://pubmed.ncbi.nlm.nih.gov/25738757/ | ### Instruction:
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Synergistic effects of combined treatment with simvastatin and exemestane on M... |
65bcf2e8ba4bd0911cf6a8ed3352e2e9 | Synergy of Omeprazole and Praziquantel In Vitro Treatment against Schistosoma mansoni Adult Worms . | [
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] | Synergy of Omeprazole and Praziquantel In Vitro Treatment against Schistosoma mansoni Adult Worms . Treatment and morbidity control of schistosomiasis relies on a single drug, praziquantel (PZQ), and the selection of resistant worms under repeated treatment is a concern. Therefore, there is a pressing need to understan... | https://pubmed.ncbi.nlm.nih.gov/26402251/ | ### Instruction:
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Synergy of Omeprazole and Praziquantel In Vitro Treatment against Schistosoma ... |
1ed70d4deb51eaba9be4d2bdbada5d16 | Inclusion criteria were proven infection with evidence of a bacterial strain of PA resistant to all β-lactams and treated with the association of at least aztreonam plus cefepime . | [
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] | Use of aztreonam in association with cefepime for the treatment of nosocomial infections due to multidrug-resistant strains of Pseudomonas aeruginosa to β-lactams in ICU patients: A pilot study. Resistance to all β-lactams is emerging among Pseudomonas aeruginosa (PA) clinical isolates. aztreonam and cefepime act syner... | https://pubmed.ncbi.nlm.nih.gov/26004874/ | ### Instruction:
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92445f629c7c8fa9a5f669f9895c4ca4 | Comparison of the additive effects of nipradilol and carteolol to latanoprost in open-angle glaucoma . | [
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] | Comparison of the additive effects of nipradilol and carteolol to latanoprost in open-angle glaucoma . To compare the effects of nipradilol and carteolol on intraocular pressure (IOP) when added to latanoprost treatment for glaucoma patients. ### methods Fifty patients with primary open-angle glaucoma were treated with... | https://pubmed.ncbi.nlm.nih.gov/16453185/ | ### Instruction:
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Comparison of the additive effects of nipradilol and carteolol to latanoprost ... |
c02a93b4a7110fb9bc0dc35cbaf0cd6e | The poly(ADP-ribose ) polymerase ( PARP ) inhibitor olaparib has recently received approval from the Food and Drug Administration ( FDA ) and European Medicines Agency ( EMA ) , with a second agent ( rucaparib ) likely to be approved in the near future . | [
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] | [] | Clinical Application of Poly(ADP-Ribose) Polymerase Inhibitors in High-Grade Serous Ovarian Cancer. : High-grade serous ovarian cancer is characterized by genomic instability, with one half of all tumors displaying defects in the important DNA repair pathway of homologous recombination. Given the action of poly(ADP-rib... | https://pubmed.ncbi.nlm.nih.gov/27022037/ | ### Instruction:
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Clinical Application of Poly(ADP-Ribose) Polymerase Inhibitors in High-Grade S... |
d2cc5f8f48a70aafe4eb86abc0c90963 | Fluvoxamine is a fairly potent inhibitor of CYP2C19 and it has the potential for causing drug-drug interactions with substrates for CYP2C19 such as imipramine , clomipramine , amitriptyline and diazepam . | [
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] | Fluvoxamine inhibits the CYP2C19-catalysed metabolism of proguanil in vitro. The potent CYP1A2 inhibitor fluvoxamine has recently been shown also to be an effective inhibitor of the CYP2C19-mediated metabolism of the antimalarial drug proguanil in vivo. The purpose of the present study was to confirm this interaction i... | https://pubmed.ncbi.nlm.nih.gov/9923577/ | ### Instruction:
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Fluvoxamine inhibits the CYP2C19-catalysed metabolism of proguanil in vitro. T... |
8d5eb6f039e442f59bb27170b6806920 | We have compared amphotericin B , flucytosine , ketoconazole and fluconazole susceptibilities of 40 clinical isolates of Candida albicans by broth microdilution in two different media : RPMI 1640 ( RPMI ) and the same medium supplemented with 18 g of glucose per L ( RPMI-2 % glucose ) . | [
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"start": ... | [] | Defining conditions for microbroth antifungal susceptibility tests: influence of RPMI and RPMI-2% glucose on the selection of endpoint criteria. We have compared amphotericin B , flucytosine , ketoconazole and fluconazole susceptibilities of 40 clinical isolates of Candida albicans by broth microdilution in two differ... | https://pubmed.ncbi.nlm.nih.gov/7559186/ | ### Instruction:
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Defining conditions for microbroth antifungal susceptibility tests: influence ... |
a0ac50dcdd622cfc2511df4110f4c9c2 | Over the past decade , paclitaxel , docetaxel , vinorelbine , gemcitabine , irinotecan , and topotecan have been introduced into the clinic . | [
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... | [] | Is cisplatin required for the treatment of non-small-cell lung cancer? Experience and preliminary results of a phase I/II trial with topotecan and vinorelbine. Platinum-based chemotherapy is considered standard treatment for advanced non-small-cell lung cancer (NSCLC). However, toxicity of most platinum-based regimens ... | https://pubmed.ncbi.nlm.nih.gov/11598413/ | ### Instruction:
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Is cisplatin required for the treatment of non-small-cell lung cancer? Experie... |
85cf1d136acd78cbd2c0e0e7ba8af4a6 | Alternatively , it may be that the adverse effects of pindolol and propranolol are due to the simultaneous blockade of both beta 1- and beta 2-adrenoceptors . | [
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Central propranolol and pindolol, but not atenolol nor metoprolol, inhibit sex... |
33b4a24c32bbaeaa9098849bae7fd55c | The combinations of irinotecan and mitomycin C or oxaliplatin have given very good results with high objective response rates and good tolerance . | [
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] | [Irinotecan in combination for colon cancer]. As a single agent, irinotecan has demonstrated efficacy in metastatic 5FU resistant colorectal metastatic cancer. Chemotherapy with fluorouracil (5FU) plus leucovorin remains a standard in the treatment of patients with metastatic colorectal cancer. It seemed logical to tes... | https://pubmed.ncbi.nlm.nih.gov/9932084/ | ### Instruction:
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[Irinotecan in combination for colon cancer]. As a single agent, irinotecan ha... |
b3ba634638d733010cbe6ea8555c17d1 | The NHB of strategy A was 31.6 QALMs versus strategy C when palbociclib was included in strategy C ; similarly , strategy A had a NHB of 13.8 QALMs versus strategy C when pertuzumab was included in strategy C. Monte-Carlo simulation demonstrated that the main factor influencing NHB of strategy A over strategy C was the... | [
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] | [] | Liver Resection for Breast Cancer Liver Metastases: A Cost-utility Analysis. To estimate the cost-effectiveness of liver resection followed by adjuvant systemic therapy relative to systemic therapy alone for patients with breast cancer liver metastasis. ### background Data on cost-effectiveness of liver resection for a... | https://pubmed.ncbi.nlm.nih.gov/28266967/ | ### Instruction:
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Liver Resection for Breast Cancer Liver Metastases: A Cost-utility Analysis. T... |
02016864b7b05842923fc562653e6d26 | In the second study 12 patients with small cell undifferentiated cancers were treated with carboplatin , etoposide and ifosfamide . | [
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] | Effects of interleukin-3 on myelosuppression induced by chemotherapy for ovarian cancer and small cell undifferentiated tumours. Two clinical studies were undertaken to study the toxicity profile and effects of interleukin-3 (rhIL-3) on chemotherapy-induced myelosuppression. Fifteen patients with recurrent ovarian carc... | https://pubmed.ncbi.nlm.nih.gov/7692922/ | ### Instruction:
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Effects of interleukin-3 on myelosuppression induced by chemotherapy for ovari... |
cbb38295f9bb8e6d792b8d943d1ea03e | 3 . Systemic ( i.v . ) pretreatment with furosemide ( 2 - 10 mg kg-1 ) increased urine volume and dose-dependently inhibited the pressor response to i.c.v . clonidine ( 10 micrograms ) , and a long-lasting depressor response to clonidine was observed . | [
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] | Furosemide inhibits the centrally-mediated pressor response to clonidine in conscious, normotensive rats. 1. The effect of furosemide on the pressor response induced by intracerebroventricular (i.c.v.) injection of clonidine was investigated in freely moving, normotensive rats with chronically implanted arterial cathet... | https://pubmed.ncbi.nlm.nih.gov/1797326/ | ### Instruction:
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f76833b73a044ef61bb52a3c0dacafb8 | Nine studies connected to the network for the PFS analysis in which necitumumab in combination with gemcitabine and cisplatin was associated with the lowest HR . | [
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First-line treatment of patients with advanced or metastatic squamous non-smal... |
aeff9357c8822f550a9039fff2c8eab1 | To evaluate the efficacy and toxicities of gemcitabine combined with ifosfamide and anthracycline chemotherapy for recurrent platinum resistant ovarian epithelial cancer . | [
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[Gemcitabine based combination chemotherapy, a new salvage regimen for recurre... |
cc21758921b269913859dccc84fcc675 | Combination of erlotinib and sorafenib , synergistic in GSC11 , induced apoptosis and autophagic cell death associated with suppressed Akt and ERK signaling pathways and decreased nuclear PKM2 and β-catenin in vitro , and tended to improve survival of nude mice bearing GSC11 brain tumor . | [
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285ff522dbf828beae54331363e1aa59 | In the first trial , paclitaxel and doxorubicin were alternated every 3 weeks in doses of 200 mg/m2 and 75 mg/m2 , respectively , for patients who had received no more than one prior chemotherapeutic regimen . | [
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Paclitaxel (Taxol)/doxorubicin combinations in advanced breast cancer: the Eas... |
d94638045c3e1a5a7b55e25f7b2727bb | Thirty-one patients with histologically proven small cell lung cancer were treated with cyclophosphamide 1 g m-2 and etoposide ( VP16 - 213 ) 125 mg m-2 both intravenously on day 1 followed by etoposide 250 mg m-2 orally on days 2 - 3 for a maximum of six courses at 3 weekly intervals . | [
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a4208d3dba815399d8e4010b689a8027 | Pemetrexed plus carboplatin followed by pemetrexed , docetaxel , atezolizumab and S-1 were performed in sequence . | [
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710177e4ab5628b7cf2962ce9a4347ee | The initial response ( IR ) was sustained for a mean ( s.d . ) of 309 ( 244 ) days with vildagliptin versus 270 ( 223 ) days for glimepiride ( p < 0.001 ) ( IR = nadir HbA1c where change from baseline > or = 0.5 % or HbA1c < or = 6.5 % within the first six months of treatment . | [
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Vildagliptin add-on to metformin produces similar efficacy and reduced hypogly... |
9e4a4ac0b5d6f5c60c5f0d73fcc3b766 | The aim of this phase I study was to determine the maximum tolerated dose of a 3-h infusion of paclitaxel , combined with carboplatin at a fixed AUC of 7 mg ml-1 min every 4 weeks for up to six cycles and to evaluate any possible pharmacokinetic interaction . | [
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4b31d5b4682f2cb6d4de9cd5ecdc3527 | All those treated with mefloquine plus artemether survived and their parasite clearance time and fever clearance time were significantly shorter than those of patients receiving quinine . | [
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070556e0b7ed1a722df98cba5e44277b | Currently available adrenal steroidogenesis inhibitors , including ketoconazole , metyrapone , etomidate , and mitotane , have variable efficacy and significant side effects , and none are approved by the US Food and Drug Administration for CS . | [
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38e86e2ea081339e207960ade6df585f | The differential effects of haloperidol and methamphetamine on time estimation in the rat . | [
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e1cbaee16f90b5f5cd216566c4f3348a | In the present study , we evaluated the efficacy and safety of the weekly combination of etoposide , leucovorin ( LV ) and 5-fluorouracil ( 5-FU ) when administered as second-line chemotherapy in patients with relapsed/refractory advanced colorectal cancer ( ACC ) , previously treated with weekly LV+5-FU . | [
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Cellular characterization of pituitary adenoma cell line (AtT20 cell) transfec... |
56767edbaaf4aa1833e32ccf779a6d71 | Reducing the duration of medication use postoperatively may also minimize the possible side effects of ketorolac and codeine , which could develop with extended periods of use . | [
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d5f7976596eb3d6b0af16a3cf786c912 | Lenalidomide plus dexamethasone is a reference treatment for relapsed multiple myeloma . | [
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8c077eeed55f1a34d9df0058007d72b1 | Following definitive treatment , patients were randomized to either cyclophosphamide 1 g/m2 intravenously every 3 weeks for 2 years , estramustine phosphate 600 mg/m2 orally daily for 2 years or to observation only . | [
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0e3638fb7225dbfb492b6e28afaefb04 | The authors report on anemia observed during preoperative paclitaxel and carboplatin chemotherapy in patients with advanced head and neck carcinoma and discuss how the use of recombinant human erythropoietin ( r-HuEPO ) ameliorates this anemia , reducing the need for subsequent packed red blood cell ( PRBC ) transfusio... | [
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31a0bb182139720ca8b79d8e68089d7e | Combination therapy with fluconazole and flucytosine in the murine model of cryptococcal meningitis . | [
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a4eaf1e008a043a0608e1e0a1e0bf452 | The consumption of meropenem or doripenem was calculated using the Anatomic Therapeutic Chemical classification and defined daily doses methodology . | [
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22debd462be9d02dd7750eb8021920c8 | After successful phase II studies , recent phase III trials established combinations of chlorambucil with anti-CD20 antibodies such as rituximab , ofatumumab and obinutuzumab as a valuable treatment option for these patients . | [
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188b16b8466b9036888f9feac1266c4b | Unorthodox antibiotic combinations including ciprofloxacin against high-level gentamicin resistant enterococci . | [
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988f81203188bfe746d002e49e6c45d7 | Randomized Trial of Lenalidomide Alone Versus Lenalidomide Plus Rituximab in Patients With Recurrent Follicular Lymphoma : CALGB 50401 ( Alliance ) . | [
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Randomized Trial of Lenalidomide Alone Versus Lenalidomide Plus Rituximab in P... |
2f4875c70156aa249196fc0eaef130a8 | Potential cost-effectiveness of rifampin vs. isoniazid for latent tuberculosis : implications for future clinical trials . | [
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Potential cost-effectiveness of rifampin vs. isoniazid for latent tuberculosis... |
029f80670066e918ad09b45caa1e326d | Treatments included once daily erlotinib , which was given alone for the first 7 days of treatments , then in combination with once daily sirolimus . | [
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A dose escalation trial for the combination of erlotinib and sirolimus for rec... |
0713ecdff351b72f27677723d0a8cc65 | Cabazitaxel effectively killed PC-3R cells , and MDR1 knockdown improved the sensitivity of PC-3R cells to docetaxel but not to cabazitaxel . | [
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bf761dcf8faf97dba0151338f99b7f8a | The results suggest that rational therapy for severe CHF includes addition of the aldosterone antagonist spironolactone to low doses of captopril ( or another ACE inhibitor ) and high doses of loop diuretics , provided renal function is adequate . | [
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2639e095391228a032ec68c2c3f598ad | The MICs of erythromycin and clindamycin for most of the LAB were within the normal range of susceptibility . | [
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5ce6e216b05e1bb1b1ed43e0bc86e44d | Based on HRs for RFS/DFS , the risk of recurrence with nivolumab was similar to that of pembrolizumab and lower than that of ipilimumab 3 mg/kg , ipilimumab 10 mg/kg , or interferon . | [
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Comparative efficacy and safety of adjuvant nivolumab versus other treatments ... |
ce0aa908b93d64279ac44dcaf232b957 | Combination therapy of infliximab and methotrexate is more effective in reducing clinical and biochemical disease activity than gold with methylprednisolone treatment in RA patients during 22 weeks of treatment , especially in the first 6 weeks . | [
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[Analysis of efficacy and safety of multiple intravenous infusion of anti-tumo... |
73b3eae39bac7bc40153d6a660377f2b | Serum homocysteine , cholesterol , retinol , alpha-tocopherol , glycosylated hemoglobin and inflammatory response during therapy with bevacizumab , oxaliplatin , 5-fluorouracil and leucovorin . | [
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869722511c63922c25884fec67a7e0cb | Reversal of drug resistance by planetary ball milled ( PBM ) nanoparticle loaded with resveratrol and docetaxel in prostate cancer . | [
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3340a0163ab0c5a4a681d3b8d9a74668 | Records of 63 patients diagnosis of IHCC who received Gemcitabine and Carboplatin ( G-C Regimen ) chemotherapy as a first line were retrospectively reviewed . | [
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Gemcitabine with carboplatin for advanced intrahepatic cholangiocarcinoma: A s... |
0bb682c2b7cf581f5630b073a89e2728 | Drugs most commonly implicated in ADRs were amoxicillin + clavulanate ( 21.87 % ) followed by ceftriaxone ( 20.31 % ) . | [
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Adverse Drug Reactions in Hospitalized Pediatric Patients: A Prospective Obser... |
c9b122c2f0b11e182b4ed52d9f390055 | Dexamethasone and piroxicam provided in the diet were found to significantly inhibit lung tumors induced by 60 mg/kg vinyl carbamate at 24 weeks whereas myo-inositol also provided in the diet , did not significantly inhibit tumor formation . | [
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Chemoprevention of vinyl carbamate-induced lung tumors in strain A mice. The a... |
7d28ca2a855a5b496c60034074c7858a | We identified 938 patients with RCC who had initially been treated with sunitinib ( n = 554 ) or sorafenib ( n = 384 ) . | [
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9e5fb2640e823bd9f6060982fa8daf28 | ( 3 ) Observed facilitatory effects of caerulein on the hypothalamic defensive attack were very similar to those observed with dopamine ( DA ) agonists such as methamphetamine and apomorphine and opposite to those with DA antagonists such as haloperidol and chlorpromazine . | [
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Facilitatory effects of caerulein on hypothalamic defensive attack in cats. Ef... |
b6851a7dde2051096158e6c807455512 | The NIBIT-MESO-1 study demonstrated the efficacy and safety of tremelimumab combined with durvalumab in patient with unresectable mesothelioma followed up for a median of 52 months [ IQR 49 - 53 ] . | [
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6cfe3dd23724e0caa786ba26a68a658f | Sorafenib has been the standard of care for a decade , and promising results for regorafenib as a second-line and lenvatinib as a first-line treatment were reported only 1 or 2 years ago . | [
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Immune Checkpoint Inhibitors in Hepatocellular Carcinoma: Opportunities and Ch... |
0a7134a3a2612a4d409a7d631f5c6260 | The addition of trastuzumab , pertuzumab , bevacizumab , or lapatinib to chemotherapy significantly ( P < .05 ) improved objective response rate ( ORR ) , time to failure ( TTF ) , and overall survival ( OS ) in patients with HER2-positive ( HER2(+ ) ) disease . | [
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ce729f6ebbcf5bb46bb08e16542fd835 | The feasibility and efficacy of an intensified procarbazine-free consolidation regimen VECOPA ( vinblastine , etoposide , cyclophosphamide , vincristine , prednisone , doxorubicin ) were investigated . | [
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Feasibility of VECOPA, a dose-intensive chemotherapy regimen for children and ... |
447854f1de95488c44ec5e39824f21d7 | The combination regimen of nivolumab plus ipilimumab demonstrates activity in metastatic uveal melanoma , with deep and sustained confirmed responses . | [
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Nivolumab and Ipilimumab in Metastatic Uveal Melanoma: Results From a Single-A... |
3727a540ed60fbcbe84867b9a216d7f7 | The FDA reviewed data in electronic format from a randomized controlled clinical trial of 1106 adult patients with newly diagnosed Philadelphia chromosome-positive CML in chronic phase , comparing imatinib with the combination of IFN-alpha and cytarabine . | [
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cd89968df90b1bb4fb356d8c717e3738 | A total of 164 patients with recurrent ovarian cancer were selected and randomly divided into two groups : experimental group ( n=82 , BEV + paclitaxel + carboplatin ) and control group ( n=82 , paclitaxel + carboplatin ) . | [
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bd252f7e7872efdd84ff4314959d2793 | Successful treatment of an adult with Kasabach-Merritt syndrome using thalidomide , vincristine , and prednisone . | [
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Successful treatment of an adult with Kasabach-Merritt syndrome using thalidom... |
b8ca06ae2a24839388168c966f0eaed6 | Superiority of sirolimus ( rapamycin ) over cyclosporine in augmenting allograft and xenograft survival in mice treated with antilymphocyte serum and donor-specific bone marrow . | [
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... | [] | Superiority of sirolimus ( rapamycin ) over cyclosporine in augmenting allograft and xenograft survival in mice treated with antilymphocyte serum and donor-specific bone marrow . sirolimus is a potent immunosuppressive agent with great therapeutic potential. The objective of our study was to evaluate the efficacy of si... | https://pubmed.ncbi.nlm.nih.gov/9039923/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
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### Input:
Superiority of sirolimus ( rapamycin ) over cyclosporine in augmenting allogra... |
ee9b23ccfb165468071d9c7bcef4f590 | Profiling of drug-metabolizing enzymes/transporters in CD33 + acute myeloid leukemia patients treated with Gemtuzumab-Ozogamicin and Fludarabine , Cytarabine and Idarubicin . | [
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] | Profiling of drug-metabolizing enzymes/transporters in CD33 + acute myeloid leukemia patients treated with Gemtuzumab-Ozogamicin and Fludarabine , Cytarabine and Idarubicin . Genetic heterogeneity in drug-metabolizing enzyme/transporter (DMET) genes affects specific drug-related cancer phenotypes. To investigate the re... | https://pubmed.ncbi.nlm.nih.gov/22584460/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Profiling of drug-metabolizing enzymes/transporters in CD33 + acute myeloid le... |
178e161c0e0960a219110932d3746c09 | In addition , anti-PCSK9 drugs ( evolocumab and alirocumab ) provide an effective solution for patients with familial hypercholesterolemia ( FH ) and statin intolerance at very high cardiovascular risk . | [
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] | [] | Treatment Strategy for Dyslipidemia in Cardiovascular Disease Prevention: Focus on Old and New Drugs. Prevention and treatment of dyslipidemia should be considered as an integral part of individual cardiovascular prevention interventions, which should be addressed primarily to those at higher risk who benefit most. To ... | https://pubmed.ncbi.nlm.nih.gov/29361723/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
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### Input:
Treatment Strategy for Dyslipidemia in Cardiovascular Disease Prevention: Focu... |
c13dbaaf1d499d927f9739805788022f | Likewise , emotional , functional well-being , and QoL aspects specifically related to lung cancer were better improved in the Gefitinib group than in the Pemetrexed group ( P<0.05 ) . | [
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] | [] | [A randomized clinical study of Gefitinib and pemetrexed as second line therapy for advanced non-squamous non-small cell lung cancer]. gefitinib and pemetrexed are drugs used as second-line therapy for advanced non-small cell lung cancer (NSCLC), although studies comparing the two drugs are limited. The aim of this stu... | https://pubmed.ncbi.nlm.nih.gov/23945243/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
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### Input:
[A randomized clinical study of Gefitinib and pemetrexed as second line therap... |
08fdd1d12a13087c9d06f4b30fd12542 | To determine efficacy and safety of the association of IL-1 receptor antagonist anakinra plus methylprednisolone in severe COVID-19 pneumonia with hyperinflammation . | [
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] | Anakinra combined with methylprednisolone in patients with severe COVID-19 pneumonia and hyperinflammation: an observational cohort study. Immunomodulants have been proposed to mitigate SARS-Cov-2-induced cytokine storm, which drives acute respiratory distress syndrome in COVID-19. ### objective To determine efficacy a... | https://pubmed.ncbi.nlm.nih.gov/33220354/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Anakinra combined with methylprednisolone in patients with severe COVID-19 pne... |
183c151df65c06b02c251456be7381a0 | When rats were given Li for 3 days , followed by a single injection of imipramine , the concentrations of desipramine in the brain and serum were higher than those in the vehicle-treated rat , although the imipramine concentrations in both tissues did not differ in Li- and in vehicle-treated rats . | [
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"... | [
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] | Effects of lithium on alterations of pharmacokinetics of imipramine and on the related changes of monoamines in rat brain. Rats were given chronically i.p. imipramine (20 mg/kg), LiCl (1 mg/kg) or both drugs to examine the effects of lithium (Li) on the alterations of imipramine pharmacokinetics in the whole brain and ... | https://pubmed.ncbi.nlm.nih.gov/2625134/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
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### Input:
Effects of lithium on alterations of pharmacokinetics of imipramine and on the... |
92082bec5072473e89c67b616f8a0e15 | Using population-based data from the province of Ontario , the benefit of first-line ipilimumab was estimated by comparing outcomes of patients treated with first-line dacarbazine over the period 2007 - 2009 with patients treated over the period 2010 - 2015 with first-line ipilimumab . | [
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"start"... | [] | A population-based study of the treatment effect of first-line ipilimumab for metastatic or unresectable melanoma. ipilimumab is an anti-CTLA4 monoclonal antibody with demonstrated efficacy for metastatic melanoma in randomized controlled trials, including in the first-line setting. Population-based outcomes directly c... | https://pubmed.ncbi.nlm.nih.gov/30789386/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
A population-based study of the treatment effect of first-line ipilimumab for ... |
383db1cc0a36e83b809ae71e8657387a | In the present study the combination of tamoxifen and bromocriptine was tried for the suppression of prolactin in prolactin secreting adenomas which were resistant to suppression with bromoergocriptine alone . | [
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] | [Bromocriptine and tamoxifen--a new therapeutic approach in suppression-resistant prolactin-secreting adenomas]. In the present study the combination of tamoxifen and bromocriptine was tried for the suppression of prolactin in prolactin secreting adenomas which were resistant to suppression with bromoergocriptine alon... | https://pubmed.ncbi.nlm.nih.gov/6924910/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
[Bromocriptine and tamoxifen--a new therapeutic approach in suppression-resist... |
84d5a3309ee9e753c55c12b8ae228c9c | The present case suggests that combination therapy with thalidomide and dexamethasone is still an alternative treatment regimen for resistant extramedullary plasmacytoma with a plasmablastic morphology . | [
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] | Refractory plasmablastic type myeloma with multiple extramedullary plasmacytomas and massive myelomatous effusion: remarkable response with a combination of thalidomide and dexamethasone. A 74-year-old man with multiple myeloma was refractory to melphalan/prednisolone (MP), high-dose dexamethasone and VAD chemotherapy.... | https://pubmed.ncbi.nlm.nih.gov/19834276/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Refractory plasmablastic type myeloma with multiple extramedullary plasmacytom... |
975865298fd67bd4b6ff56a8d8929f5f | Among 788 eligible patients , the median ( SD ) age was 59 ( 22 - 74 ) years ; 263 patients were assigned to doxorubicin plus cisplatin treatment , 263 patients to docetaxel plus cisplatin treatment , and 262 patients to paclitaxel plus carboplatin treatment . | [
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] | Effect of Taxane Plus Platinum Regimens vs Doxorubicin Plus Cisplatin as Adjuvant Chemotherapy for Endometrial Cancer at a High Risk of Progression: A Randomized Clinical Trial. The efficacy of taxane plus platinum regimens has been demonstrated for advanced or recurrent endometrial cancer; however, it has not been ass... | https://pubmed.ncbi.nlm.nih.gov/30896757/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Effect of Taxane Plus Platinum Regimens vs Doxorubicin Plus Cisplatin as Adjuv... |
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